Table 4.

Analyzing the relationship between SII and oncological outcomes using multivariable logistic regression.

		Lymph Node			Advanced Tumor Grading			Locoregionally Extended State
Characteristic	OR	95% CI	p-value	OR	95% CI	p-value	OR	95% CI	p-value
SII (Reference: low)
High	2.91	1.09, 7.72	0.03	2.09	1.00, 4.40	0.05	2.96	1.44, 6.08	0.003
Age	1.10	0.33, 3.72	0.86	0.79	0.30, 2.07	0.644	1.06	0.42, 2.70	0.89
Smoke (Reference: no)
Smoke	0.56	0.22, 1.41	0.22	0.82	0.33, 2.02	0.680	1.30	0.53, 3.19	0.56
Sex (Reference: male)
Female	0.52	0.18, 1.51	0.23	0.31	0.11, 0.91	0.034	0.51	0.19, 1.36	0.18
Clinical tumor stage
(Reference: cTa/cTis/cT1)
cT2	5.35	1.97, 14.56	0.001	45.06	9.47, 214.31	<0.001	31.41	6.73, 146.46	<0.001
cT3/cT4	10.58	3.70, 30.19	<0.001	27.08	5.66, 129.51	<0.001
Goodness-of-fit test	Hosmer–Lemeshow test		0.89			0.21			0.82
AUC
Model with SII		AUC: 0.79			AUC: 0.80			AUC: 0.81
Model without SII		AUC: 0.76 (+3%)			AUC: 0.77 (+3%)			AUC: 0.76 (+5%)
(p = difference model)			0.17			0.16			0.03

SII = Systemic immune inflammation index; OR = Odds ratio; CI = Confidence interval; AUC: Area under the curve.