Table 5.

Multivariable Cox regression analysis to predict RFS, CSS, and OS before surgery.

		Relapse-Free Survival			Cancer-Specific Survival			Overall Survival
	HR	95% CI	p-value	HR	95% CI	p-value	HR	95% CI	p-value
PIV (Reference: low)
High	1.89	1.12, 3.19	0.017	1.07	0.57, 2.02	0.819	1.64	1.05, 2.56	0.029
Age	0.77	0.40, 1.46	0.427	1.27	0.53, 3.04	0.579	1.11	0.61, 2.02	0.717
Smoking status (Reference: no)
Smoke	0.91	0.53, 1.55	0.744	1.30	0.62, 2.73	0.478	1.25	0.74, 2.10	0.401
Sex (Reference: male)
Female	0.86	0.49, 1.52	0.624	1.47	0.78, 2.80	0.230	1.06	0.64, 1.75	0.811
Clinical tumor condition
(Reference: cTa/cTis/cT1)
cT2	1.58	0.82, 3.05	0.168	1.03	0.42, 2.53	0.938	1.25	0.69, 2.27	0.450
cT3/cT4	7.14	3.90, 13.06	<0.001	8.77	4.13, 18.61	<0.001	4.02	2.24, 7.19	<0.001
Harrel’s index
Model accuracy			0.72			0.72			0.66
Model accuracy without PIV			0.68 (+4%)			0.71 (+1%)			0.63 (+3%)
(p = difference model)			0.01			0.81			0.03

PIV = Pan-immune inflammation value; HR = Hazard ratio; CI = Confidence interval.