Table 6.

Multivariable Cox regression analysis following surgery to predict RFS, CSS, and OS.

		Relapse-Free Survival			Cancer-Specific Survival			Overall Survival
Characteristic	HR	95% CI	p-value	HR	95% CI	p-value	HR	95% CI	p-value
PIV (Reference: low)
High	1.74	1.04, 2.92	0.034	1.30	0.69, 2.43	0.412	1.58	1.00, 2.49	0.048
Age	0.99	0.52, 1.88	0.994	1.46	0.61, 3.49	0.387	1.21	0.67, 2.21	0.517
Smoking status (Reference: no)
Smoke	1.26	0.72, 2.19	0.403	2.13	1.02, 4.44	0.043	1.73	1.02, 2.92	0.039
Sex (Reference: male)
Female	1.42	0.77, 2.61	0.258	1.78	0.92, 3.45	0.084	1.30	0.77, 2.18	0.314
Tumor grading
(Reference: pT0/pTa/pTispT1)
pT2	1.67	0.65, 4.28	0.283	0.98	0.31, 3.11	0.981	1.54	0.70, 3.40	0.276
pT3/pT4	2.84	1.14, 7.09	0.025	2.88	1.17, 7.11	0.021	3.23	1.59, 6.53	0.001
Lymphovascular invasion	1.03	0.41, 2.54	0.94	0.97	0.38, 2.44	0.957	0.90	0.44, 1.81	0.774
Lymph node invasion	3.85	2.12, 6.99	<0.001	4.26	1.89, 9.61	<0.001	3.12	1.74, 5.60	<0.001
Adjuvant chemotherapy	1.31	0.73, 2.34	0.349	0.44	0.19, 1.00	0.05	0.61	0.34, 1.08	0.092
C-index
Model with PIV			0.78			0.76			0.73
Model without PIV			0.77 (+1%)			0.76			0.72 (1%)
(p = difference model)			0.03			0.67			0.04

PIV = Pan-immune inflammation value; HR = Hazard ratio; CI = Confidence Interval.