Table 1.

The relationship between the complement and coagulation systems.

Factor	Substrate	Action of the Complement/Coagulation Factor on the Substrate: Activated (+)/Inactivated (−)	References
Factor XIIa	C1r	+	[37]
Factor XIII, Fibrinogen, Fibrin, Thrombin	MASP1	+	[38,40,42,43]
Fibrin, Thrombin	MASP2	+	[43,46,47]
Thrombin, Factor VII, Factor IXa, Factor Xa, Factor Xia, Kallikrein, Plasmin	C3 and C5	+	[40,48,49,50,51,52,53]
Platelets	C3	+	[50,51,54,55]
Thrombin	DAF	+ (− complement activity)	[41]
MAC, C5a	Tissue Factor	+	[56,57]
Complement	Heparin	-	[58]