Table 1.
Age in years, median (range) | 58 (20–74) |
Sex, no. (%) | |
Male | 32 (52.5) |
Female | 29 (47.5) |
Diagnosis, no. (%) AML (according to WHO 2022)
|
40 (65.6) 31 (50.8) 17 (27.9) 7 (11.5) 3 (4.9) 2 (3.3) 1 (1.6) 1 (1.6) 2 (3.3) 7 (11.5) 3 (4.9) 2 (3.3) 1 (1.6) 1 (1.6) |
MDS (according to WHO 2022)
|
18 (29.5) 6 (9.8) 6 (9.8) 5 (8.2) 1 (1.6) |
CMML
|
2 (3.3) 1 (1.6) 1 (1.6) |
CML (in blast crisis) | 1 (1.6) |
Risk stratification according to genetics, no. (%) | |
High-risk | 45 (73.8) |
Intermediate | 12 (19.7) |
Favorable | 4 (6.6) |
HCT-CI, no. (%) | |
0 | 21 (34.4) |
1–2 | 19 (31.1) |
≥3 | 19 (31.1) |
Unknown | 2 (3.3) |
Disease status at transplant, no. (%) | |
Relapsed/refractory | 41 (67.2) |
Untreated disease | 19 (31.1) |
CR | 1 (1.6) |
Number of transplant(s), no. (%) | |
First | 58 (95.1) |
Second | 3 (4.9) |
Conditioning regimen, no. (%) | |
FLAMSA + melphalan (100–200 mg/m2) | 29 (47.5) |
FLAMSA + treosulfan (30 g/m2) | 22 (36.1) |
FLAMSA + Cy 60 mg/kg + TBI 4 Gy | 9 (14.8) |
FLAMSA + Cy 60 mg/kg + TBI 8 Gy | 1 (1.6) |
FLAMSA + TBI 4 Gy | 1 (1.6) |
Donor, no. (%) | |
Matched unrelated donor (MUD) | 32 (52.5) |
Matched related donor (MRD) | 12 (19.7) |
Haploidentical | 10 (16.4) |
Mismatched unrelated donor 9/10 (MMUD) | 7 (11.5) |
GVHD prophylaxis, no. (%) | |
Antithymocyte globulin 3 × 5 mg/kg BW | 5 (8.2) |
Antithymocyte globulin 3 × 10 mg/kg BW | 30 (49.2) |
Antithymocyte globulin 3 × 20 mg/kg BW | 7 (11.5) |
Post-Transplant cyclophosphamide 50 mg/kg BW | 15 (24.6) |
None | 4 (6.6) |