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. 2024 Jan 26;16(3):532. doi: 10.3390/cancers16030532

Table 1.

Patient demographics.

Age in years, median (range) 58 (20–74)
Sex, no. (%)
Male 32 (52.5)
Female 29 (47.5)
Diagnosis, no. (%)
AML (according to WHO 2022)
  • with defining genetic abnormalities
    • -
      AML, myelodysplasia-related
    • -
      AML with NPM1 mutation
    • -
      AML with RUNX1::RUNX1T1 fusion
    • -
      AML with CEBPA mutation
    • -
      AML with KMT2A rearrangement
    • -
      AML with CBFB::MYH11 fusion
  • myeloid neoplasm post-cytotoxic therapy

  • defined by differentiation
    • -
      acute myelomonocytic leukemia
    • -
      AML with minimal differentiation
    • -
      acute basophilic leukemia
    • -
      acute monocytic leukemia

40 (65.6)
31 (50.8)
17 (27.9)
7 (11.5)
3 (4.9)
2 (3.3)
1 (1.6)
1 (1.6)
2 (3.3)
7 (11.5)
3 (4.9)
2 (3.3)
1 (1.6)
1 (1.6)
MDS (according to WHO 2022)
  • with bi-allelic TP53 inactivation

  • with increased blasts 1

  • with increased blasts 2

  • MDS with low blasts

18 (29.5)
6 (9.8)
6 (9.8)
5 (8.2)
1 (1.6)
CMML
  • CMML0

  • CMML1

2 (3.3)
1 (1.6)
1 (1.6)
CML (in blast crisis) 1 (1.6)
Risk stratification according to genetics, no. (%)
High-risk 45 (73.8)
Intermediate 12 (19.7)
Favorable 4 (6.6)
HCT-CI, no. (%)
0 21 (34.4)
1–2 19 (31.1)
≥3 19 (31.1)
Unknown 2 (3.3)
Disease status at transplant, no. (%)
Relapsed/refractory 41 (67.2)
Untreated disease 19 (31.1)
CR 1 (1.6)
Number of transplant(s), no. (%)
First 58 (95.1)
Second 3 (4.9)
Conditioning regimen, no. (%)
FLAMSA + melphalan (100–200 mg/m2) 29 (47.5)
FLAMSA + treosulfan (30 g/m2) 22 (36.1)
FLAMSA + Cy 60 mg/kg + TBI 4 Gy 9 (14.8)
FLAMSA + Cy 60 mg/kg + TBI 8 Gy 1 (1.6)
FLAMSA + TBI 4 Gy 1 (1.6)
Donor, no. (%)
Matched unrelated donor (MUD) 32 (52.5)
Matched related donor (MRD) 12 (19.7)
Haploidentical 10 (16.4)
Mismatched unrelated donor 9/10 (MMUD) 7 (11.5)
GVHD prophylaxis, no. (%)
Antithymocyte globulin 3 × 5 mg/kg BW 5 (8.2)
Antithymocyte globulin 3 × 10 mg/kg BW 30 (49.2)
Antithymocyte globulin 3 × 20 mg/kg BW 7 (11.5)
Post-Transplant cyclophosphamide 50 mg/kg BW 15 (24.6)
None 4 (6.6)