Table 3.

Tumour response one- and six-months post treatment and overall response one- and six-months post treatment.

Patient Number	Site of the Tumours	Tumour Response One Month Post Treatment	Tumour Response Six Months Post Treatment	Overall Response One Month Post Treatment	Overall Response Six Months Post Treatment	Necrosis Observed at One Month Post Treatment
1	Left hind leg	SD	PR	SD	PR	✓
2	Left front leg	PR	PD	PR	PD	✓
3	Left front leg	PR	PD	PR	PD	✓
4	Right inguinal region	CR	CR	CR	CR	✓
5	Right hind leg	PR	CR	PR	SD
	Right scapula	PR	CR
	Left hind leg	PR	RT
	Left inguinal region	PR	CR
6	Right hind leg	SD	RT	SD	RT
7	Left scapula	CR	CR	CR	CR
8	Right dorsum	PR	RT	PR	RT
9	Left hind leg	PR	CR	PR	CR
10	Right front leg	CR	CR	CR	CR	✓
11	Left ear	CR	CR	CR	CR
	Dorsal part of the neck	CR	CR
	Right abdominal region	CR	CR
	Perianal region	CR	CR
12	Prepuce	CR	CR	CR	CR
13	Left front leg	CR	CR	CR	CR	✓
	Right lip commissure	CR	CR
14	Dorsum	CR	CR	CR	CR
	Left abdominal region	CR	CR
	Left hind leg	CR	CR
	Left hind leg	CR	CR
	Tail base	CR	CR
	Vulva	CR	CR
15	Left elbow	CR	CR	CR	CR
16	Right inguinal region	PR	CR	PR	CR	✓
17	Chin	SD	RT	SD	RT
	Right thoracic region	CR	CR
	Right hind leg	SD	RT
	Right hind leg	CR	CR
18	Perianal region	CR	PD	CR	PD
19	Left hind leg	PR	CR	PR	CR
20	Left abdominal region	PR	PR	PR	PR
	Left front leg	PR	PR
	Right hind leg	PR	PR
21	Right hind leg	CR	CR	CR	CR
22	Right orbital region	PR	LTFU	PR	LTFU
	Perianal region	CR	LTFU
	Perianal region	CR	LTFU
	Right hind leg	CR	LTFU
23	Right front leg	PR	PR	SD	PD
	Left front leg	PR	CR
	Sternal region	SD	SD
	Right orbital region	PR	CR
24	Right hind leg	PR	CR	PR	CR
25	Prepuce	CR	CR	PR	CR
	Right hind leg	CR	CR
	Perianal region	CR	CR
	Right abdominal region	CR	CR
26	Prepuce	SD	PD	SD	PD
27	Right ear	PR	CR	PR	CR
28	Left ear	PR	CR	PR	CR
29	Left abdominal region	PR	CR	PR	CR
30	Left thoracic region	CR	CR	CR	RT
	Left thoracic region	CR	CR
	Left hind leg	CR	CR
	Right ear	CR	CR
	Right thoracic region	CR	CR
	Left inguinal region	CR	CR
31	Left hind leg	PR	CR	PR	CR
32	Tail	CR	CR	CR	CR
33	Right front leg	PR	CR	PR	CR	✓
34	Left hind leg	SD	RT	SD	RT
	Left hind leg	SD	RT
	Scrotum	SD	RT
	Prepuce	SD	RT
	Left front leg	SD	RT
35	Prepuce	PR	CR	SD	RT
	Right hind leg	PR	CR
36	Right front leg	PR	CR	PR	CR	✓
37	Right abdominal region	PR	PR	PR	PR	✓
	Perianal region	PR	PR
38	Right lip corner	PR	CR	PR	CR
39	Left front leg	PR	LTFU	PR	LTFU	✓
	Left front leg	PR	LTFU
40	Frontal region	CR	CR	CR	CR	✓
41	Left ear	SD	RT	SD	RT
42	Left hind leg	SD	SD	SD	SD
43	Perianal region	PR	PR	PR	PR
44	Right hind leg	PR	CR	PR	CR
45	Left axillary region	PR	CR	PR	CR	✓
46	Right hind leg	PR	CR	PR	CR	✓
47	Right lip commissure	CR	CR	CR	CR
48	Right hind leg	SD	PD	SD	PD

CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease; RT, re-treatment prior to response evaluation; LTFU, lost to follow-up; ✓, necrosis observed. Evaluation of response to treatment is based on the RECIST criteria [21].