Figure 1.

Annual count of cuproptosis-related publications utilizing the PubMED search engine. In 2021, the first cuproptosis-related article was published [11], cited 65 times. In 2022, Tsvetkov and colleagues introduced the concept of a distinct form of regulated cell death induced by copper, known as cuproptosis, cited 844 times. The same year saw a notable surge, with 279 publications exploring cuproptosis, followed by a continued increase in 2023 with 580 publications. As of 2024, an additional 40 publications have been dedicated to the study of cuproptosis thus far [12].