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. 2024 Feb 4;13(3):281. doi: 10.3390/cells13030281

Figure 1.

Figure 1

Schematic representation of a heat map of the retinal pigment epithelium (RPE), and a diagram of the distribution of photoreceptors of the human retina: (a) concentric zones of the adult human eye RPE: P1—fovea and parafovea; P2—perifovea; P3—the immediate periphery (or equatorial region); P4—a ring of RPE cells identified for the first time, resembling the RPE cells of zone P2; and P5—the far periphery, ending with the ora serrata; the dark blue staining indicates small hexagonal RPE cells of regular shape; a decrease in the blue color saturation with a transition to yellow indicates that the cell area of the RPE increases, cell hexagonality is disrupted, cells become more elongated, and cell density decreases in the monolayer; (b) the concentric zones of M and L cone distribution in the adult retina; (c) the concentric zones of S cone distribution in the adult retina; and (d) the concentric zones of rod distribution in the adult retina. Interpretation has been conducted in accordance with [1] and [38]. The more saturated the color, the higher the cell density. RPE—retinal pigment epithelium; L/M—Long wavelength/Medium wavelength cones; and S—Short wavelength cones.