Table 2.
List of commonly used macrocyclic HSP90, N-terminal, and C-terminal ATPase inhibitors.
| Site of Action | Class of Inhibitors |
Examples | Ref. |
|---|---|---|---|
| N-terminal ATPase | Benzoquinone | Geldanamycin (GDA) | [175] |
| Ansamycin | Tanespimycin (17-AAG) Alvespimycin (17-DMAG) Retaspimycin (IPI-504) |
[50] | |
| Macrolide | Radicol (RDC) | [176] | |
| Radicol-based: Gantespib (STA-9090) CCTO18159 NVP-AUY922 KW-2478 AT13387 |
|||
| Chimeric Inhibitors (GDA+RDC) | Radanamycin Radamide Radester |
[177] | |
| Purine Scaffold | PU3 | ||
| Pyrazole | PU24FC1 CCTO18159 |
||
| C-terminal ATPase | Coumarin Antibiotics | Novobiocin Novobiocin-based: Cholorobiocin Coumermycin |
[165] |
| Synthetic Inhibitors | EGCG (Epigallocatechin-3-gallate) Cisplatin, Taxol, Withaferin |
[178] |