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. 2024 Jan 26;16(3):544. doi: 10.3390/cancers16030544

Figure 2.

Figure 2

Coregulator exchange at RXR/RAR heterodimers. RARs function as modulators of transcription by recruiting coregulator complexes having HDAC activity. Retinoids function as a ligand activating or blocking gene transcription mediated via RXR/RAR heterodimers. This figure was designed by the authors. HDAC, histone deacetylase; NCoR, nuclear receptor corepressor complex; RA, retinoic acid; RARE, retinoic acid-response element; SMRT, silencing mediator of retinoic acid and thyroid hormone receptor.