Table 2.

Therapies targeting NETs.

Interventions		Effect	References
Clinical trial	Dnase Ⅰ	Removes DNA components from NETs, degrades NETs, and reduces NET deposition.	[106]
	Untravenous vitamin C	Inhibits NETosis, unspecified. 1	[129]
Observational Study	HMGB1 inhibitors, metformin	Improve efferocytosis and NET clearance.	[16]
Laboratory research	DNase I	Removes DNA components from NETs, degrades NETs, and reduces NET deposition.	[20,26,28,31,95,132,133]
	PAD4 inhibitors	Reduce histone citrullination and thus block NETosis.	[79,135]
	NE inhibitors	Inhibit the formation of NETs and reduce cytotoxicity.	[26,31,62]
	HMGB1 inhibitors	Block the signaling pathway and inhibit the formation and release of NETs.	[36]
	anti-PD-L1 antibodies		[94]
	inhibitors of p38 MAPK kinase		[95]
	Osteopontin (OPN)	Phosphorylation binds to histones with high affinity, thereby reducing cytotoxicity and reducing the formation of NETs.	[142]
	Protectin D1 (PD1)	Inhibit NETosis, unspecified.	[139]
	Deferasirox		[140]
	Mesenchymal stem cells (MSCs)		[141]
	Colchicine		[143]
	Disulfiram		[144]
	Methoxyeugenol		[145]
	Anti-CLEC5A		[146]
	Selinexor		[147]
	Stimulation of the ear vagus nerve		[148]

¹ It is not clear in the literature in what form the interference reduces the contents of NETs.