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. 2024 Jan 26;25(3):1543. doi: 10.3390/ijms25031543

Figure 3.

Figure 3

Uhrf2 gene deletion results in impaired sensorimotor gating as measured by prepulse inhibition test (PPI). (A) A schematic of the PPI setup, the sequence of acoustic stimuli (S1 and S2), and the startle response measurement are presented. (B) Results of the PPI are shown for wild-type mice (gray, n = 12), heterozygous mice (green, n = 12), and Uhrf2 knockout mice (red, n = 10) at sound pressure levels of 74, 78, and 82 dB. (C) The results show a significant difference in PPI between Uhrf2+/+ and Uhrf2+/− mice compared to Uhrf2−/− mice. Sidak’s multiple comparisons yielded the following values: **** p < 0.0001, *** p = 0.0004, and ns (0.07), respectively.