Figure 3.

The general influence of platelet-rich plasma (PRP) on biological features of biomaterials for skin tissue engineering (STE) applications. Cell culture experiments in vitro indicated that fibroblasts or keratinocytes, which were settled on biomaterials enriched with PRP, exhibited higher adhesion, viability and proliferation when compared to cells cultured on unmodified biomaterial. Moreover, such modified biomaterials promoted the expression of fibroblast-specific genes and the production of skin extracellular matrix (ECM) proteins. In vivo studies showed that biomaterials enriched with PRP possessed a better ability to accelerate skin wound healing when compared to biomaterials without PRP. This figure was prepared by the authors themselves based on results from the latest scientific reports, which were described in Section 5.1. Created with BioRender.com (accessed on 19 January 2024).