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. 2024 Jan 26;25(3):1525. doi: 10.3390/ijms25031525

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Poly-ε-caprolactone/Pluronic F127/PRP nerve guidance conduit (NGC) for peripheral nerve injury regeneration. This biomaterial (A) was implanted in the damaged recurrent laryngeal nerve (RLN) of rabbits (B,E–G). Poly-ε-caprolactone/Pluronic F127/PRP NGC enabled the penetration of oxygen and nutrients while hindering the translocation of inflammatory cells (C). Moreover, this biomaterial promoted the recovery of Schwann cells (SCs) and axons (D). Reprinted/adapted with permission from Ref. [101]. Copyright 2023, Nature Communications.