Figure 7.

The general influence of platelet-rich plasma (PRP) on biological features of biomaterials for cartilage and osteochondral tissue applications. Cell culture experiments in vitro indicated that chondrocytes or stem cells, grown on biomaterials enriched with PRP (A) or on biomaterials cultured in medium with PRP (B), exhibited higher viability, proliferation and the ability to produce cartilage-related markers when compared to cells cultured on unmodified biomaterial or maintained in culture medium without PRP. In vivo studies showed that biomaterials enriched with PRP with settled cells possessed a better ability to regenerate cartilage and osteochondral defects when compared to biomaterials without PRP and loaded cells. Abbreviations: SOX-9—SRY-box transcription factor 9; GAGs—glycosaminoglycans. This figure was prepared by the authors themselves, based on results from the latest scientific reports, which are described in Section 7.1. Created with BioRender.com (accessed on 19 January 2024).