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. 2024 Jan 26;25(3):1525. doi: 10.3390/ijms25031525

Table 2.

The influence of platelet-rich plasma (PRP) on properties of selected polymer-based biomaterials for skin tissue engineering applications.

Biomaterial Platelet-Rich Plasma
Application		 Main Advantages Ref.
Freeze-dried scaffold composed of collagen and glycosaminoglycans (GAGs)

  • PRP 1 added to biomaterial after fabrication process—incubation for 1 h at 37 °C

  • The PRP 1—enriched collagen-GAG scaffold possessed the ability to release growth factors for up to 14 days in a sustained manner

  • The extract obtained from the collagen-GAG-PRP biomaterial significantly promoted the proliferation of HSFs 2 and BMSCs 3 when compared to the medium supplemented with FBS 4

  • The collagen-GAG-PRP biomaterial enhanced the production of anti-inflammatory markers by human macrophages and supported the growth of coculture including human fibroblasts and keratinocytes

  • The biomaterial supported angiogenesis in vitro and in vivo more potently than the collagen-GAG scaffold

 [75]
Polydopamine-modified collagen sponge scaffolds (pDA-CSS)

  • PRP 1 added to biomaterial after fabrication process—incubation for 12 h at room temperature

  • The pDA-CSS@PRP biomaterial also significantly promoted the adhesion, migration and proliferation of human keratinocytes and human endothelial cells

  • It promoted angiogenesis and wound healing in mice with full-thickness skin defects

 [114]
Chitosan/silk fibroin dressing loaded with silver nanoparticles and modified by stearic acid (CHT-SF/Ag/SA)

  • PRP 1 added to biomaterial after fabrication process (a small amount dropped onto the biomaterial)

  • The CHT-SF/Ag/SA/PRP sponge possessed a great ability to absorb liquid and also to keep moisture up to approx. 19 h

  • It was also characterized by the gradual release of protein for almost 48 h

  • It possessed the ability to inhibit the growth of Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans without cytotoxic effects toward HSFs 2 and hUCMSCs 5

  • The CHT-SF/Ag/SA/PRP biomaterial exhibited the best wound-healing properties in vivo when compared to both the CHT-SF/Ag/SA biomaterial, commercial dressing containing silver (Acosin, Shenzhen Agt. Pharm. Co., Ltd., Shenzen, China) as well as gauze and gauze covered by PRP

 [131]

1 PRP—platelet-rich plasma; 2 HSFs—human skin fibroblasts; 3 BMSCs—bone-marrow-derived stem cells; 4 FBS—fetal bovine serum; 5 hUCMSCs—human umbilical-cord-derived mesenchymal stem cells.