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. 2024 Feb 2;25(3):1826. doi: 10.3390/ijms25031826

Table 5.

Genes associated with Brugada syndrome [6,108,118,119,120,121].

Gene Protein
SCN5A Sodium channel protein type 5 subunit α
SCN10A Sodium channel protein type 10 subunit α
SCN1B Sodium channel subunit β-1
SCN2B Sodium channel subunit β-2
SCN3B Sodium channel subunit β-3
KCND2 Potassium voltage-gated channel subfamily D member 2
KCND3 Potassium voltage-gated channel subfamily D member 3
KCNE2 Potassium voltage-gated channel subfamily E member 2
KCNE3 Potassium voltage-gated channel subfamily E member 3
KCNE5 Potassium voltage-gated channel subfamily E regulatory β subunit 5
KCNH2 Potassium voltage-gated channel subfamily H member 2
HCN4 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
KCNJ8 ATP-sensitive inward rectifier potassium channel 8
CACNA1C Voltage-dependent L-type calcium channel subunit α-1C
CACNA2D1 Voltage-dependent calcium channel subunit α-2/δ-1
CACNB2 Voltage-dependent L-type calcium channel subunit β-2
ABCC9 ATP-binding cassette sub-family C member 9
FGF12 Fibroblast growth factor 12
GPD1L Glycerol-3-phosphate dehydrogenase 1-like protein
PKP2 Plakophilin-2
RANGRF Ran guanine nucleotide release factor
SEMA3A Semaphorin-3A
SLMAP Sarcolemmal membrane-associated protein
TRPM4 Transient receptor potential cation channel subfamily M member 4