Table 6.

Shanghai Score System [122,123].

Feature	Points
1.ECG (12 lead/ambulatory)—one item from this category must apply
(a)Spontaneous type 1 Brugada ECG pattern at nominal or high leads	3.5
(b)Fever-induced type 1 Brugada ECG pattern at nominal or high leads	3
(c)(Type 2 or 3 Brugada ECG pattern that converts with provocative drug challenge	2
2.Family history—only award points once for the highest score within this category
(a)First- or second-degree relative with definite BrS	2
(b)Suspicious SCD (fever, nocturnal, Brugada aggravating drugs) in a first- or second-degree relative	1
(c)Unexplained SCD <45 years in first- or second-degree relative with negative autopsy	0.5
3.Clinical history—only award points once for the highest score within this category
(a)Unexplained cardiac arrest or documented VF/polymorphic VT	3
(b)Nocturnal agonal respirations	2
(c)Suspected arrhythmic syncope	2
(d)Syncope of unclear mechanism/unclear etiology	1
(e)Atrial flutter/fibrillation in patients <30 years without alternative etiology	0.5
4.Genetic test result
Probable pathogenic mutation in BrS susceptibility gene	0.5

Score (at least 1 ECG finding): ≥3.5 points: probable and/or definite BrS; 2–3 points: possible BrS; <2 points: non-diagnostic. BrS—Brugada syndrome; SCD—sudden cardiac death; VF—ventricular fibrillation; VT—ventricular tachycardia.