Figure 3.

Vericiguat and main pathophysiological effects. Vericiguat has pleiotropic effects. It is an sGC enhancer which acts regardless of NO presence. It induces an increase in cGMP activating several molecular pathways. It acts by improving myocardial energetics, exploiting an anti-remodelling, anti-inflammatory and anti-fibrotic effect. It reduces pre- and post-load left ventricular filling pressures, improving also kidney blood flow. sGC: soluble guanylate cyclase; cGMP: cyclic guanosine monophosphate; PAP: pulmonary arterial pressure; PCWP: post-capillary wedge pressure.