Table 3.
Reported somatic mutation by gene and breast cancer subtype in patients from Latin America.
| Gene | Frequency (%) in a Molecular Subtype of Breast Cancer | p-Value * | |||
|---|---|---|---|---|---|
| HR+/HER2+ (n = 20) | HR−/HER2+ (n = 11) | HR+/HER2− (n = 69) | TNBC (n = 115) | ||
| TP53 | 7 (7.29) | 3 (3.13) | 21 (21.88) | 65 (67.71) | 0.002 |
| PIK3CA | 12 (17.14) | 8 (11.43) | 23 (32.86) | 27 (38.57) | 2.8 × 10−4 |
| FLT3 | 0 (0.00) | 0 (0.00) | 0 (0.00) | 15 (100.00) | 0.002 |
| AKT1 | 0 (0.00) | 0 (0.00) | 10 (90.91) | 1 (9.09) | 0.001 |
| CDKN2A | 0 (0.00) | 0 (0.00) | 4 (100.00) | 0 (0.00) | 0.048 |
| CDH1 | 0 (0.00) | 0 (0.00) | 5 (100.00) | 0 (0.00) | 0.023 |
| PTEN | 0 (0.00) | 0 (0.00) | 4 (66.67) | 2 (33.33) | 0.420 |
| RB1 | 0 (0.00) | 0 (0.00) | 1 (20.00) | 4 (80.00) | 0.841 |
| NOTCH1 | 1 (33.33) | 0 (0.00) | 1 (33.33) | 1 (33.33) | 0.407 |
* p-value obtained from Fisher’s exact test.