Table 1.
GVHD/leukaemia scoring system.
| Score 1 | 0 | 1 | 2 | 3 |
|---|---|---|---|---|
| Acute weight loss 2 | <5% | 5–9.9% | 10–14.9% | >15% |
| Chronic weight loss 3 | <5% | 5–6.9% | 7–14.9% | >15% |
| Posture | Normal | Slight hunching | Moderate hunching | Severe hunching |
| Activity | Normal | Slightly reduced activity | Reduced activity and slow movement | Slow to no movement with reduced gait or shuffling |
| Hindlimb function | Normal gait | Unable to stand on hindlimbs | Mild paresis | Severe paresis |
| Fur | Normal | Mild to moderate ruffling | Severe ruffling and hair loss | >50% hair loss |
| Skin integrity | Normal | Scaling of paws and/or tail | Scaling of additional areas | Denuded skin |
1 Mice were monitored daily if they obtained a score of 2 in any category (except fur) and euthanised if they obtained a score of 3 in any category. 2 Acute weight loss was calculated from the greatest weight over the past 7 days. 3 Chronic weight loss was calculated from Day 0 weight.