TABLE 2.
Cytokine determinations in lung on days 5 and 15 after infection
| Mouse group | Concn of cytokine expresseda
|
|||
|---|---|---|---|---|
| IFN-γ (ng/ml) | IL-10 (pg/ml) | TNF-α (pg/ml) | IL-6 (pg/ml) | |
| Day 5 | ||||
| B6129F2/J | 49 ± 8 | 309 ± 41 | 177 ± 13 | 300 ± 60 |
| IL-6−/− | ||||
| Untreated | 11 ± 1* | 283 ± 42 | 171 ± 10 | 20 ± 9** |
| Treated with antiIL-10 antibody | 47 ± 5 | NDb | 167 ± 8 | ND |
| Day 15 | ||||
| B6129F2/J | 12 ± 1 | 313 ± 56 | 121 ± 10 | 760 ± 10 |
| IL-6−/− | ||||
| Untreated | 4 ± 1* | 320 ± 25 | 124 ± 12 | <10** |
| Treated with antiIL-10 antibody | 11.5 ± 1 | ND | ND | ND |
a
Data are expressed as means ± standard errors for groups of five mice each. All statistics were calculated according to the Mann-Whitney test. *, P < 0.015 versus B6129F2/J (two-tailed test); **, P < 0.01 versus B6129F2/J (two-tailed test).
b
ND, not determined.