TABLE 3.
Protective efficacy of WRSS1 measured with the guinea pig keratoconjunctivitis model
| Immunizing straina | No. of eyes with indicated ratingb
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Postimmunizationc
|
Postchallenged
|
|||||||
| 0 | 1 | 2 | 3 | 0 | 1 | 2 | 3 | |
| Expt 1 | ||||||||
| WRSS1 | 16 | 0 | 0 | 0 | 11 | 5 | 0 | 0 |
| None (nonimmunized) | NAe | NA | NA | NA | 0 | 0 | 0 | 16 |
| Expt 2 | ||||||||
| WRSS1 | 16 | 0 | 0 | 0 | 10 | 4 | 2 | 0 |
| None (nonimmunized) | NA | NA | NA | NA | 0 | 0 | 1 | 15 |
a
In each experiment, 16 eyes were inoculated with WRSS1 and 16 were left uninoculated.
b
Ratings are described in the text.
c
Ratings after the first and second immunizations were identical.
d
Animals were challenged 4 weeks after the second immunization with virulent strain S. sonnei 53G.
e
NA, not applicable.