Figure 7.

Effect G6PDi−1 on electrical activity and peak amplitude of extracellular H₂O₂ production during spontaneous SLEs induced by 4AP. (a) Representative traces of local field potential (black) and extracellular H₂O₂ (green) that are recorded before and after addition of G6PDi−1 (orange). Below, at expanded time scale, examples of associated extracellular H₂O₂ changes during spontaneous epileptiform events are shown. Frequency of spontaneous seizures (b,c) and peak amplitude of hydrogen peroxide release during spontaneous epileptiform events (d,e), that occurred in the presence of 4AP (black), after the addition of G6PDi−1 (orange) and after washing (gray), illustrated with examples from two slices. (f) Summary of normalized H₂O₂ release amplitudes during spontaneous SLEs in the presence of 4AP, after addition of G6PDi−1 and after washing (n = 4).