Table 4.
Treatment-related adverse events.
| Adverse Events | Any Grade n (%) |
Grade 1–2 n (%) |
Grade 3–4 n (%) |
|---|---|---|---|
| Non-haematological (patients, n = 55) | |||
| Diarrhea | 28 (50.9) | 25 (45.5) | 3 (5.5) |
| Nausea | 45 (81.8) | 44 (80.0) | 1 (1.8) |
| Vomiting | 27 (49.1) | 25 (45.5) | 2 (3.6) |
| Dyspepsia | 7 (12.7) | 7 (12.7) | 0 (0) |
| Constipation | 22 (40.0) | 20 (36.4) | 2 (3.6) |
| Cystitis | 9 (16.4) | 9 (16.4) | 0 (0) |
| Sensory neuropathy | 41 (74.5) | 39 (70.9) | 2 (3.6) |
| Motor | 22 (40.0) | 20 (36.4) | 2 (3.6) |
| Pain | 42 (76.3) | 39 (70.9) | 3 (5.5) |
| Stomatitis | 30 (54.5) | 30 (54.5) | 0 (0) |
| Skin | 17 (30.9) | 17 (30.9) | 0 (0) |
| Nail disorder | 7 (12.7) | 6 (10.9) | 1 (1.8) |
| Allergic reaction | 7 (12.7) | 5 (9.1) | 2 (3.6) |
| Dyspnea | 15 (27.3) | 14 (25.5) | 1 (1.8) |
| Fever in absence of infection | 8 (14.5) | 8 (14.5) | 0 (0) |
| Fatigue | 50 (90.9) | 36 (65.5) | 14 (25.5) |
| Anorexia | 44 (80.0) | 41 (74.5) | 3 (5.5) |
| Myalgia | 34 (61.8) | 33 (60) | 1 (1.8) |
| Arthralgia | 27 (49.1) | 27 (49.1) | 0 (0) |
| Haematological (patients, n = 50) | |||
| Neutropenia 1 | 42 (84) | 15 (30) | 27 (54) |
| Thrombocytopenia 2 | 43 (86) | 33 (66) | 10 (20) |
| Anemia 3 | 45 (90) | 45 (90) | 0 (0) |
| Increased creatinine | 5 (10) | 5 (10) | 0 (0) |
1: The category of neutropenia includes reports of neutropenia and decreased neutrophil count. 2: The category of thrombocytopenia includes reports of thrombocytopenia and decreased platelet count. 3: The category of anemia includes reports of anemia and decreased hemoglobin count.