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An interphase fluorescence in situ hybridization (FISH) study with a dual-color break-apart probe set containing two probes flanking the breakpoint in the CBFB gene, showing a nucleus with inv(16)(p13.1 q22). An intact gene results in the colocalization of the two probes, producing a fusion (yellow) signal. The presence of CBFB rearrangement is indicated by separate red and green signals.
