Figure 2.

Multivariable-adjusted ORs (95%(CIs)) of low (<10th percentile) and high (>90th percentile) fetal growth in the second and third trimester pregnancy associated with maternal iron supplementation throughout pregnancy on stratum 1 (80 or 40 mg/d) and stratum 2 (40 or 20 mg/d). The reference group was 40 mg/d dose group for stratum 1 and 20 mg/d dose group for stratum 2. Abbreviations: EFW—estimated fetal weight; FL—femur length; HC—head circumference; BD—biparietal diameter; AC—abdominal circumference. All fetal growth parameter values were corrected for gestational age (weeks) at the time of ultrasound measurement using residual method. * Models were adjusted for sex of baby, maternal age (years), maternal early-pregnancy BMI categories (normal weight (ref.), overweight, obese), family SES (low (ref.), medium, high), smoking during pregnancy (no (ref.), yes), fiber intake at the first trimester, log-serum ferritin (µg/L) at the first trimester, cortisol (µg/dl) at the first trimester, carrier of HFE gene mutation (no (ref.), yes for stratum 2), and gestational weight gain (kg, only for third trimester analysis). The significance of numbers in bold is p-value < 0.05. Low (<10th percentile) or high (>90th percentile) fetal growth versus normal fetal growth (10th to 90th percentile) for gestational age-adjusted EFW, FL, HC, BD, or AC based on distribution percentile from the study population as reference. The diamonds represent OR and the whisker plots represent 95% CIs. n—number of cases infants (%); N—number of total infants.