Fig 2. Chronic GLB treatment further impairs glucose-induced insulin secretion in Cyb5r3 βKO.

a and b: Plasma insulin (a) blood glucose (b) levels in WT and Cyb5r3 βKO treated with GLB under free feeding condition (n = 4). c and d: Plasma insulin level and its area under the curve (c) and blood glucose levels and its area under the curve (d) in WT and Cyb5r3 βKO treated with GLB during glucose tolerance test (n = 4). *P < 0.05 by two-way ANOVA followed by Tukey’s test. Data represent means ± SEM.