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. 2024 Feb 9;19(2):e0297555. doi: 10.1371/journal.pone.0297555

Fig 4. β-cell dedifferentiation in Cyb5r3 βKO also develops by HFD feeding or aging.

Fig 4

a: Representative images from pancreatic sections of WT and Cyb5r3 βKO fed a HFD stained with Aldh1a3 (green), Insulin (red), and DAPI (blue). Scale bars: 50 μm. b: Quantification of Aldh1a3 positive cells in WT and Cyb5r3 βKO fed a HFD (n = 4). c and d: Plasma insulin (c) and blood glucose (d) levels in WT and Cyb5r3 βKO fed a HFD under free feeding condition (n = 4–6). e: Representative Aldh1a3 staining (green) in islets from pancreatic sections of aged WT and Cyb5r3 βKO (n = 3). Scale bars: 50 μm. f: Quantification of Aldh1a3 positive cells in aged WT and Cyb5r3 βKO (n = 3). *P < 0.05 by unpaired Student’s t-test. Data represent means ± SEM.