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. 2024 Feb 8;20(1):2309693. doi: 10.1080/21645515.2024.2309693

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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 1. — Development and testing of human ESR1 targeting vaccines. (a) Diagram of E1 region for [E1-,E3-] adenoviral ESR1 vaccines. (b,c) C57BL/6J mice (b) and HLA-A2-Tg (c) were vaccinated with indicated viruses and assessed for ESR1-specific T cell responses at 2 weeks post vaccination through IFNγ ELISPOT (n = 5 mice/group). (d) HLA-A2 tg mice were vaccinated with the indicated viruses and assessed for ESR1-specific T cell responses at 2 weeks post vaccination through IFNγ ELISPOT (n = 3–4 mice/group). Error bars represent SEM. Select p values shown. Significance determined via T test with Bonferroni correction for multiple comparisons. ****p < .0001.