Table 3.
Detailed analysis of the outcomes of the metaanalysis with subgroup analysis based on the study design
| Outcome measures (n) | Overall effect (OR, 95% CI, P value, I2) | RCTs only, n (OR, 95% CI, P value, I2) |
|---|---|---|
| Mortality (6) | OR 0.84, 95% CI 0.71–0.98, P = 0.03, I2 = 0% | n = 4 (OR 0.99, 95% CI 0.73–1.33, P = 0.93, I2 = 0%) |
| AKI (6) | OR 0.74, 95% CI 0.57–0.96, P = 0.03, I2 = 37% | n = 4 (OR 0.54, 95% CI 0.39–0.75, P = 0.0003, I2 = 0%) |
| Need for RRT (5) | OR 0.79, 95% CI 0.60–1.02, P = 0.07, I2 = 0% | n = 3 (OR 1.10, 95% CI 0.54–2.24, P = 0.80, I2 = 0%) |
| Hyperchloremia (3) | OR 0.47, 95% CI 0.34–0.67, P < 0.0001, I2 = 0% | n = 3 (OR 0.47, 95% CI 0.34–0.67, P < 0.0001, I2 = 0%) |
| Hospital LOS (4) | MD 0.67 days, 95% CI −1.51, 2.84, P = 0.55, I2 = 87% | n = 3 (MD −0.66 days, 95% CI −1.10, −0.23, P = 0.003, I2 = 0%) |
| ICU LOS (3) | MD 0.27 days, 95% CI −0.36, 0.90, P = 0.40, I2 = 47% | n = 2 (MD 0.66 days, 95% CI −1.32, 2.64, P = 0.51, I2 = 60%) |
AKI indicates acute kidney injury; CI, confidence interval; ICU, intensive care unit; IS, isotonic saline; LOS, length of stay; MD, mean difference; N/A, not applicable for outcomes that were reported by ≤1 study; NR, not reported; OR, odds ratio; RCTs, randomized controlled trials; RRT, renal replacement therapy.