Table 2. Heterogeneity and pleiotropy tests for the associations between PBC and CTD.

MR analysis	Heterogeneity test		Pleiotropy test
	Q	Q-pval	Egger_intercept	se	p
PBC-SLE	111.110	<0.001	-0.009	0.032	0.776
PBC-RA	125.150	<0.001	0.006	0.015	0.708
PBC-SS	27.007	0.571	0.001	0.019	0.941
PBC-SSc	34.035	0.653	0.092	0.073	0.216
SLE-PBC	46.706	<0.001	0.0509	0.034	0.162
RA-PBC	21.723	0.001	-0.041	0.050	0.442
SS-PBC	3.188	0.074	NA	NA	NA
SSc-PBC	0.869	0.833	-0.068	0.044	0.219