Table 3. Hazard ratios for associations of SPI-II and CHA2DS2-VASc risk scores with incident ischemic stroke and with incident major hemorrhage in the POINT trial (n=4,841).
Point estimates reported from models that include the risk scores as continuous variables reflect the hazard ratio for the outcome per unit increase in the risk score. Point estimates reported from models that include the risk scores as dichotomized variables reflect the hazard ratio of the outcome in patients above the median score relative to those at or below the median score. CI: confidence interval; HR: hazard ratio
| Risk score | Model | HR for ischemic stroke [95% CI] |
P value | HR for major hemorrhage [95% CI] |
P value |
|---|---|---|---|---|---|
| SPI-II | Continuous (unit increase) | 1.15 [1.09–1.21] |
<0.001 | 1.11 [0.95–1.29] |
0.16 |
| Dichotomized (≤3 vs >3) | 1.84 [1.44–2.35] |
<0.001 | 1.80 [0.90–3.57] |
0.10 | |
| CHA2DS2-VASc | Continuous (unit increase) | 1.14 [1.05–1.24] |
0.003 | 1.34 [1.06–1.70] |
0.01 |
| Dichotomized (≤2 vs >2) | 1.18 [0.93–1.50] |
0.18 | 2.34 [1.15–4.75] |
0.02 |