Table 2.
Univariate and multivariable Cox proportional-hazards regression models for various variables in predicting the recurrence and mortality of HBV-HCC
| End point and variables | Univariate Cox regression | Multivariate Cox regression | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| group 1 | group 2 | group 3 | group 4 | |||||||||||||||||
| HR | (95% CI) | p value | HR | (95% CI) | p value | HR | (95% CI) | p value | HR | (95% CI) | p value | HR | (95% CI) | p value | ||||||
| Recurrence | ||||||||||||||||||||
| G1 versus non-G1 | 1.26 | 0.80–2.00 | 0.323 | 1.08 | 0.66–1.76 | 0.760 | ||||||||||||||
| G2 versus non-G2 | 0.83 | 0.42–1.65 | 0.593 | 0.85 | 0.42–1.74 | 0.658 | ||||||||||||||
| G3 versus non-G3 | 1.41 | 0.90–2.22 | 0.134 | 1.50 | 0.91–2.47 | 0.114 | ||||||||||||||
| G4 versus non-G4 | 0.63 | 0.39–1.02 | 0.060 | 0.69 | 0.42–1.15 | 0.156 | ||||||||||||||
| Age >60 versus ≤60 | 1.15 | 0.75–1.76 | 0.536 | 1.16 | 0.74–1.80 | 0.522 | 1.14 | 0.73–1.78 | 0.556 | 1.06 | 0.68–1.68 | 0.789 | 1.12 | 0.72–1.74 | 0.628 | |||||
| Male versus female | 1.38 | 0.82–2.33 | 0.223 | 1.47 | 0.86–2.53 | 0.157 | 1.50 | 0.87–2.57 | 0.145 | 1.40 | 0.82–2.42 | 0.222 | 1.37 | 0.79–2.38 | 0.256 | |||||
| Tumor size >5 cm versus ≤5 cm | 2.53 | 1.66–3.88 | <0.001 | *** | 2.75 | 1.69–4.47 | <0.001 | *** | 2.75 | 1.70–4.46 | <0.001 | *** | 3.03 | 1.85–4.96 | <0.001 | *** | 2.89 | 1.79–4.66 | <0.001 | *** |
| Microinvasion Y versus N | 1.93 | 1.25–2.98 | 0.003 | ** | 1.21 | 0.73–2.01 | 0.465 | 1.22 | 0.73–2.05 | 0.440 | 1.17 | 0.71–1.95 | 0.539 | 1.16 | 0.70–1.93 | 0.564 | ||||
| Cirrhosis Y versus N | 1.58 | 1.03–2.43 | 0.037 | * | 1.78 | 1.11–2.84 | 0.016 | * | 1.77 | 1.10–2.83 | 0.018 | * | 1.71 | 1.06–2.74 | 0.027 | * | 1.72 | 1.08–2.74 | 0.023 | * |
| Tumor grade 34 versus 12 | 1.84 | 1.20–2.81 | 0.005 | ** | 1.76 | 1.11–2.81 | 0.017 | * | 1.78 | 1.13–0.280 | 0.013 | * | 1.81 | 1.15–2.85 | 0.011 | * | 1.70 | 1.06–2.71 | 0.026 | * |
| AFP >100 ng/mL versus ≤100 ng/mL | 1.39 | 0.91–2.14 | 0.128 | 0.86 | 0.52–1.43 | 0.561 | 0.85 | 0.52–1.40 | 0.525 | 0.82 | 0.50–1.35 | 0.447 | 0.88 | 0.53–1.45 | 0.617 | |||||
| Mortality | ||||||||||||||||||||
| G1 versus non-G1 | 1.57 | 0.75–3.28 | 0.230 | 1.49 | 0.66–3.37 | 0.339 | ||||||||||||||
| G2 versus non-G2 | 1.18 | 0.41–3.39 | 0.753 | 1.20 | 0.40–3.59 | 0.745 | ||||||||||||||
| G3 versus non-G3 | 1.55 | 0.74–3.23 | 0.247 | 1.94 | 0.84–4.46 | 0.120 | ||||||||||||||
| G4 versus non-G4 | 0.33 | 0.13–0.86 | 0.024 | * | 0.26 | 0.09–0.77 | 0.015 | * | ||||||||||||
| Age >60 versus ≤60 | 0.58 | 0.27–1.26 | 0.167 | 0.55 | 0.24–1.26 | 0.156 | 0.55 | 0.24–1.28 | 0.165 | 0.50 | 0.22–1.16 | 0.108 | 0.50 | 0.22–1.15 | 0.103 | |||||
| Male versus female | 1.39 | 0.57–3.40 | 0.466 | 1.68 | 0.66–4.25 | 0.277 | 1.61 | 0.63–4.11 | 0.324 | 1.46 | 0.57–3.78 | 0.430 | 1.22 | 0.47–3.20 | 0.681 | |||||
| Tumor size >5 cm versus ≤5 cm | 3.99 | 1.91–8.33 | <0.001 | *** | 3.09 | 1.36–7.00 | 0.007 | ** | 3.35 | 1.47–7.61 | 0.004 | ** | 3.89 | 1.66–9.10 | 0.002 | ** | 3.99 | 1.76–9.06 | 0.001 | ** |
| Microinvasion Y versus N | 3.28 | 1.47–7.33 | 0.004 | ** | 1.71 | 0.70–4.17 | 0.237 | 1.64 | 0.68–3.99 | 0.274 | 1.50 | 0.61–3.67 | 0.375 | 1.48 | 0.61–3.62 | 0.390 | ||||
| Cirrhosis Y versus N | 1.45 | 0.72–2.95 | 0.300 | 1.92 | 0.86–4.27 | 0.110 | 2.02 | 0.89–4.58 | 0.092 | 1.84 | 0.82–4.16 | 0.141 | 1.84 | 0.83–4.10 | 0.134 | |||||
| Tumor grade 34 versus 12 | 1.89 | 0.93–3.83 | 0.077 | 1.42 | 0.63–3.19 | 0.400 | 1.56 | 0.72–3.39 | 0.257 | 1.53 | 0.71–3.30 | 0.280 | 1.14 | 0.49–2.66 | 0.770 | |||||
| AFP >100 ng/mL versus ≤100 ng/mL | 2.39 | 1.14–5.02 | 0.022 | * | 1.57 | 0.64–3.80 | 0.323 | 1.39 | 0.60–3.24 | 0.447 | 1.35 | 0.59–3.12 | 0.477 | 1.80 | 0.75–4.31 | 0.189 | ||||
*p < 0.05.
**p < 0.01.
***p < 0.001.