A, Quantification of LSK, SLAM-LSK and GMP in PBS versus 6-OHDA-treated mice 3 days after MI (n=10 mice PBS, n=9 6-OHDA, two-tailed Welch’s t test, four independent experiments). B, Immunofluorescence Perilipin staining and C, adipocyte quantification in controls versus 6-OHDA injected mice, all on day 3 after MI (n=12 PBS, n=9 6-OHDA, two-tailed Welch’s t test, four independent experiments). D, Flow cytometry histograms and quantification of lipid content in SLAM-LSK, LSK, and GMP in controls versus 6-OHDA treated mice, all 3 days after MI (n=10 PBS, n=10 6-OHDA, two-tailed Welch’s t test, four independent experiments). E, Experimental design of single leg denervation. F, Immunofluorescent staining of adipocytes in sham versus denervated femurs. G, Quantification of adipocyte size in sham denervated versus denervated femurs in mice on day 3 after MI (n=10, two-tailed paired t test). H, Difference in GMP proliferation between the two legs (sham leg vs. denervated leg) in MI and control mice (n=5 control mice and n=6 MI mice, two-tailed Mann-Whitney test, four independent experiments) I, Graphical abstract. Data are displayed as mean±SEM.