Table 2.

Characteristics of thyroid AEs

Type of thyroid dysfunction, n (%)
Hypothyroidism	36 (17.3)
Overt hypothyroidism	29 (13.9)
Subclinical hypothyroidism	7 (3.4)
Thyrotoxicosis	12 (5.8)
Overt thyrotoxicosis	6 (2.9)
Subclinical thyrotoxicosis	6 (2.9)
Isolated hypothyroxinemia	3 (1.4)
Isolated hyperthyroxinemia	0 (0.0)
Time to onset of thyroid dysfunction, median (IQR), months
Hypothyroidism	3.5 (2.6–6.0)
Thyrotoxicosis	1.3 (1.2–2.7)
Isolated hypothyroxinemia	3.1 (2.2–5.0)
Duration of thyroid dysfunction, median (IQR), months
Hypothyroidism	8.4 (4.0–14.4)
Thyrotoxicosis	2.4 (1.8–4.2)
Isolated hypothyroxinemia	10.7 (10.1–12.7)
Resolution of thyroid dysfunction, n (%)
Hypothyroidism	4/36 (11.1)
Thyrotoxicosis	12/12 (100.0)
Isolated hypothyroxinemia	1/3 (33.3)
CTCAE grade, n (%)
Grade 1	25 (49.0)
Grade 2	26 (51.0)

IQR, interquartile range; CTCAE, Common Terminology Criteria for Adverse Events.