Table 3.
Secondary Outcomes
| Group C (n=42) | Group P (n=42) | P-value | |
|---|---|---|---|
| CAM | |||
| 1 day after surgery | 13 (12, 15) | 15 (14, 17) | <0.001 |
| 2 days after surgery | 12 (11, 13) | 14 (13, 16) | <0.001 |
| 3 days after surgery | 12 (11, 12) | 13 (12, 14) | 0.004 |
| MAP-related indicators | |||
| Baseline, (mmHg) | 98.5 ± 10.13 | 98 ± 10 | 0.821 |
| Mean, (mmHg) | 88.63 ± 6.7 | 85 ± 8.3 | 0.03 |
| Minimum, (mmHg) | 69.81 ± 9.59 | 64.9 ± 9.43 | 0.005 |
| Percentage of stable time, (%) | 0.6 ± 0.14 | 0.45 ± 0.14 | <0.001 |
| SctO2-related indicators | |||
| Baseline, (%) | 75.28 ± 4.02 | 74.44 ± 5.01 | 0.397 |
| Mean, (%) | 77.26 ± 3.96 | 75.3 ± 4.49 | 0.039 |
| Minimum, (%) | 71.69 ± 4.51 | 68.77 ± 6.46 | 0.019 |
| Absolute decrease, (%) | 3.59 ± 0.66 | 5.19 ± 0.92 | 0.163 |
| Relative decrease, (%) | 4 (1, 9) | 6 (1, 12) | 0.185 |
| Desaturation < 90% of the Baseline, n (%) | 8 (19%) | 15 (35.7%) | 0.087 |
| AUT< 90% of the baseline | 0 (0, 0) | 0 (0, 14) | 0.042 |
| Drug dosage | |||
| C/P, (mg) | 170.46 ± 9.23 | 787.56 ± 37.23 | <0.001 |
| Remifentanil, (μg) | 836.50 (498.95, 1225) | 751.03 (529.25, 1200) | 0.879 |
| Sufentanil, (μg) | 40 (30, 40) | 35 (30, 40) | 0.376 |
| Rocuronium, (mg) | 60 (50, 70) | 60 (58.75, 80) | 0.956 |
| Noradrenaline, (μg) | 160.40 (88.80, 291.05) | 334.20 (194.20, 573.75) | 0.001 |
| Intraoperative adverse events, n (%) | |||
| Hypoxia | 6 (14.3) | 2 (4.8) | 0.265 |
| Hypotension | 33 (78.6) | 36 (85.7) | 0.57 |
| Hypertension | 10 (23.8) | 11 (26.2) | 1 |
| Bradycardia | 5 (11.9) | 6 (14.3) | 1 |
| Tachycardia | 1 (2.4%) | 3 (7.1) | 0.616 |
| Quality of awake | |||
| Time to being fully alert from the end of drug administration (OAA/S > 5, min) | 23.30 ± 12.61 | 20.76 ± 10.00 | 0.308 |
| Ramsay scores | 2.42 ± 0.36 | 2.51 ± 0.70 | 0.266 |
| BCS scores | 1.85 ± 0.62 | 1.86 ± 0.31 | 0.833 |
| PONV, n (%) | 6 (14.3%) | 5 (11.9%) | 0.746 |
| Wake delay, n (%) | 0 | 0 | 1 |
| VAS | |||
| 1 day after surgery | 3 (2.75, 4) | 3 (3, 5) | 0.262 |
| 2 days after surgery | 2 (1.75, 2) | 2 (2, 4) | 0.108 |
| 3 days after surgery | 1 (0, 2) | 1 (1, 2) | 0.345 |
Notes: Data are presented as the mean ± SD, median (interquartile range), or number of patients (%).
Abbreviations: C, Ciprofol; P, Propofol; CAM, Confusion assessment method; MAP, Mean arterial pressure; Scto2, Cerebral tissue oxygen saturation; AUT, Area under the threshold; OAA/S, Observer’s assessment of alertness/sedation; Ramsay, Ramsay Sedation Scale; BCS, Bruggrmann comfort scale; PONV, Post-operative nausea and vomiting; SD, standard deviation; VAS, visual analogue scale.