Table 5.
Logistic Regression and Sensitivity Analysis Among MAP, SctO2, and POD
| Unadjusted | Adjusted 1 | Adjusted 2 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| P | OR | 95% CI | P | OR | 95% CI | P | OR | 95% CI | |
| Sedative medication | |||||||||
| Propofol (Reference) | |||||||||
| Ciprofol | 0.252 | 0.370 | (0.068, 2.025) | 0.175 | 0.290 | (0.048, 1.735) | 0.344 | 0.360 | (0.043, 2.982) |
| MAP-related indicators | |||||||||
| Minimum, mmHg | 0.002 | 0.838 | (0.748, 0.938) | 0.003 | 0.812 | (0.709, 0.93) | 0.003 | 0.784 | (0.669, 0.918) |
| Percentage of stable time, % | 0.008 | 0.926 | (0.875, 0.98) | 0.014 | 0.925 | (0.868, 0.984) | 0.013 | 0.907 | (0.840, 0.980) |
| SctO2-related indicators | |||||||||
| Mean, % | 0.007 | 0.801 | (0.618, 0.942) | 0.020 | 0.813 | (0.683, 0.967) | 0.026 | 0.810 | (0.672, 0.975) |
| Minimum, % | <0.001 | 0.55 | (0.396, 0.764) | 0.01 | 0.443 | (0.239, 0.822) | 0.014 | 0.407 | (0.198, 0.833) |
| Absolute decrease, % | 0.046 | 1.134 | (1.002, 1.284) | 0.008 | 1.125 | (1.055, 1.423) | 0.011 | 1.255 | (1.054, 1.493) |
| Relative decrease, % | 0.001 | 1.324 | (1.121, 1.564) | 0.002 | 1.557 | (1.183, 2.049) | 0.004 | 1.826 | (1.213, 2.748) |
| Desaturation | 0.021 | 0.199 | (0.050, 0.787) | 0.016 | 0.138 | (0.028, 0.688) | 0.017 | 0.126 | (0.023, 0.695) |
| AUT | <0.001 | 1.056 | (1.026, 1.087) | 0.014 | 1.096 | (1.018, 1.779) | 0.019 | 1.137 | (1.021, 1.276) |
Notes: Adjusted 1: adjusted for age, gender, MMSE, and duration of anesthesia. Adjusted 2: adjusted for age, gender, MMSE, duration of anesthesia, hypertension, diabetes, and coronary artery disease.
Abbreviations: MAP, Mean arterial pressure; Scto2, Cerebral tissue oxygen saturation; AUT, Area under the threshold.