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. 2024 Feb 9;7(2):e2355380. doi: 10.1001/jamanetworkopen.2023.55380

Figure 2. Plasma Concentrations of Cytokines and Brain-Associated Blood-Based Biomarkers Among Patients Who Underwent Bariatric Surgery.

Figure 2.

Repeated measures analysis of variance were conducted to assess changes in circulating factors over time. Significant changes over time are indicated by P values. Complete data for all parameters on both time points were available for 110 participants, except for interleukin-1β (IL-1β), for which data from 111 participants were available. For illustrative purposes 3 extreme high IL-1β values (7.59 pg/mL, 12.75 pg/mL, and 3.94 pg/mL) at baseline are not shown. At the 2 year time point, 2 extreme high IL-1β values (5.12 and 3.26 pg/mL) was not included for illustrative purposes. Individual values for every plasma marker are presented in eTable 4 in Supplement 1. BDNF indicates brain derived neurotrophic factor; NFL = neurofilament light chain; PAI-1 plasminogen activator inhibitor-1. Dots indicate individual data points; bars, medians; bars, IQRs; and whiskers, ranges.