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. 2024 Feb 10;22:58. doi: 10.1186/s12951-024-02329-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Design and experimental characterization of Tr67. a Schematic diagram illustrating the trimerization of Nb67 nanobody fused with the optimal trimerization unit 5ff (see its amino-acid sequence of the fusion monomer of Nb67 with 5ff in (Additional file 1: Table S1). b SEC and Native-PAGE analysis of Tr67, showing high trimerization tendency and conformational homogeneity. c BLI measurement of the binding kinetics of the monovalent Nb67 and Tr67 to the immobilized RBD of SARS-CoV-2 pseudovirus (Omicron BA.1). d Neutralizing activities of Nb67 and Tr67 against SARS-CoV-2 pseudovirus (Omicron BA.1). Three independent experiments were performed