Table 3.

Univariate and multivariate analyses of OS, PFS, and PPS.

	Univariate analysis			Multivariate analysis
	HR	95% CI	p Value	HR	95% CI	p Value
(a) OS
Period A	1.00	–	–	1.00	–	–
Period B	0.87	0.74–1.02	0.089	0.89	0.76–1.04	0.142
Period C	0.75	0.64–0.87	<0.001	0.77	0.66–0.91	0.002
Period D	0.63	0.54–0.75	<0.001	0.64	0.53–0.76	<0.001
(b) PFS for first-line chemotherapy
Period A	1.00	–	–	1.00	–	–
Period B	0.95	0.81–1.12	0.089	0.96	0.81–1.13	0.621
Period C	0.75	0.64–0.88	<0.001	0.76	0.64–0.89	<0.001
Period D	0.68	0.58–0.80	<0.001	0.68	0.58–0.81	<0.001
(c) PPS for first-line chemotherapy
Period A	1.00	–	–	1.00	–	–
Period B	0.83	0.70–0.97	0.023	0.84	0.71–1.00	0.044
Period C	0.81	0.69–0.95	0.008	0.87	0.74–1.03	0.100
Period D	0.74	0.63–0.88	<0.001	0.76	0.64–0.91	0.003

CI, confidence interval; HR, hazard ratio; OS, overall survival; PFS, progression-free survival; PPS, post-progression survival.