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. 2024 Feb 9;15:20417314231203824. doi: 10.1177/20417314231203824

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© The Author(s) 2024

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Figure 5. — Concentration of cytokines in the blood serum of mice at 6 weeks post-injury, and their interaction with other molecules present in ASC secretome. (a) The concentration (pg/ml) of pro-inflammatory—IL-1β, IL-6, IFN-γ and anti-inflammatory—IL-4 cytokines in the blood serum of SCI mice was assessed using multiplex-based ELISA. Secretome group (CM) showed decreased levels of pro-inflammatory cytokines (IL1-β: 6.463 ± 2.383; IL-6: 2.286 ± 1.460; IFN-γ: 1.573 ± 0.704), and increased levels of the anti-inflammatory cytokine (IL-4: 0.696 ± 0.247), when compared to NB- (IL-4: 0.390 ± 0.256; IL1-β: 10.864 ± 1.026; IL-6: 84.702 ± 38.767; IFN-γ: 9.976 ± 3.174) and SH- (IL-4: 0.606 ± 0.363; IL1-β: 4.232 ± 1.106; IL-6: 1.143 ± 1.143; IFN-γ: 2.871 ± 1.521) treated groups. (b) Representative networks of molecules present in ASC secretome, and respective receptors and signaling molecules, based on their role on inflammation and immune response (in green), and neurogenesis and axonogenesis (in blue), identified using STRINGS bioinformatics tools. in Mean ± SEM; n = 7 for SH and CM groups; n = 4 for NB group; *p < 0.05.