Table 3.
Expression levels of proteins and phosphorylation level of Drp1 and ERK in the co-cultured groups (mean ± SD)
| Group | Drp1 | ERK1/2 | p-Drp1S616 | p-ERK1/2T202Y204 |
|---|---|---|---|---|
| wtT | 3.67 ± 2.08 | 4.00 ± 1.00 | 4.33 ± 1.53 | 2.67 ± 0.58 |
| wtT + PD-1 mAb | 2.67 ± 0.58 | 6.33 ± 4.93 | 5.33 ± 1.15 | 5.67 ± 0.58 |
| shDT + PD-1 mAb | 3.00 ± 1.00 | 2.67 ± 0.58 | 4.67 ± 1.53 | 4.33 ± 2.08 |
| oeDT + PD-1 mAb | 4.33 ± 3.21 | 2.67 ± 0.58 | 8.33 ± 3.21 | 6.67 ± 2.08 |
| wtT + A549 | 3.00 ± 1.00a | 3.00 ± 1.00 | 5.33 ± 2.31a | 3.67 ± 1.15a |
| shNT + A549 | 4.67 ± 3.79 | 2.33 ± 0.58 | 5.33 ± 1.53 | 4.67 ± 1.53 |
| shDT + A549 | 3.67 ± 1.15 | 3.67 ± 0.58 | 4.33 ± 2.08 | 3.67 ± 2.08 |
| oeNT + A549 | 3.67 ± 1.15 | 3.00 ± 1.00 | 4.67 ± 1.53 | 4.67 ± 0.58 |
| oeDT + A549 | 4.67 ± 1.53 | 2.67 ± 0.58 | 5.00 ± 1.00b | 5.67 ± 0.58b |
| wtT + PBS + A549 | 8.33 ± 2.08 | 3.00 ± 1.00 | 5.33 ± 3.21 | 4.67 ± 1.53 |
| wtT + PD-1 mAb + A549 | 4.00 ± 1.73 | 3.00 ± 1.00 | 6.33 ± 1.53 | 7.33 ± 1.15c |
| shDT + PD-1 mAb + A549 | 10.00 ± 5.29 | 3.33 ± 1.53 | 5.33 ± 1.53c | 4.67 ± 1.53d |
| oeDT + PD-1 mAb + A549 | 7.33 ± 3.79a | 5.33 ± 2.52 | 9.67 ± 3.21abc | 13.33 ± 1.53abcd |
The same superscript letter (e.g., a, b, c) indicates a significant difference between the groups (p < 0.05). Abbreviations: wtT: wild-type CD3+ T cells; shDT: CD3+ T cells with Drp1 knockdown; oeDT: CD3+ T cells with Drp1 overexpression; shNT and oeNT: negative control groups of T-shDrp1 and T-oeDrp1, respectively; PD-1 mAb: programmed cell death protein 1 monoclonal antibody; PBS: phosphate-buffered saline