. 2024 Feb 10;9:29. doi: 10.1038/s41541-024-00819-x

Table 4.

Experimental design and protection results of four mosquito bite challenge experiments

Experiment ID	Total administrations	AB317	Naïve (no vaccine)	RTS,S dose levels
RTS,S 2x	2	5/7 71.4%	0/7 0%	0/7 0%	0/7 0%	0/7 0%	0/7 0%	1/7 14.3%
RTS,S 3x-1	3	5/7 71.4%	1/7 14.3%	3/7 42.9%	3/7 42.9%	3/7 42.9%	4/7 57.1%	3/7 42.9%
RTS,S 3x-2	3	4/7 57.1%	0/7 0%	0/7 0%	0/7 0%	1/7 14.3%	5/7 71.4%	1/7 14.3%
RTS,S 3x-3	3	6/7 85.7%	0/7 0%	1/7 14.3%	2/7 28.6%	3/7 42.9%	4/7 57.1%	6/7 85.7%

Experiment ID

Total administrations

AB317

Naïve (no vaccine)

RTS,S dose levels

0.05 μg

0.2 μg

1 μg

5 μg

10 μg

RTS,S 2x

5/7

71.4%

0/7

1/7

14.3%

RTS,S 3x-1

5/7

71.4%

1/7

14.3%

3/7

42.9%

3/7

42.9%

3/7

42.9%

4/7

57.1%

3/7

42.9%

RTS,S 3x-2

4/7

57.1%

0/7

1/7

14.3%

5/7

71.4%

1/7

14.3%

RTS,S 3x-3

6/7

85.7%

0/7

1/7

14.3%

2/7

28.6%

3/7

42.9%

4/7

57.1%

6/7

85.7%

Results are shown as the fraction and percentage of protected mice over the number challenged. Experimental ID represents the immunogen (RTS,S), the number of administrations (eg 2x = two administrations, and the individual experiment number (eg -1)). For the AB317 groups, only one administration was given 16 h prior to challenge.