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. Author manuscript; available in PMC: 2025 Jan 1.
Published in final edited form as: J Pain. 2023 Aug 5;25(1):142–152. doi: 10.1016/j.jpain.2023.07.028

Table 4.

Synopsis of Minimally Important Difference and Responsiveness Metrics Across Six Trials

Variable PEG BPI Total BPI Interference BPI Severity PEG-BPI Difference*
Cronbach’s alpha
 Median .73 .89 .88 .84 −.11 to −.16
 Weighted Mean .75 .89 .88 .83 −.08 to −.14
Minimally Important difference (MID)
Global anchor – A Little Better
 Median 1.25 1.26 1.41 0.87 −.16 to +.38
 Weighted Mean 1.28 1.06 1.28 0.81 .00 to +.47
0.35 standard deviation (SD)
 Median 0.74 0.67 0.81 0.62 −.07 to +.12
 Weighted Mean 0.77 0.71 0.84 0.65 −.07 to +.12
0.50 standard deviation (SD)
 Median 1.05 0.95 1.15 0.88 −.10 to +.17
 Weighted Mean 1.09 1.03 1.16 0.92 −.07 to +.17
1 SEM
 Median 1.08 0.66 0.77 0.73 +.31 to +.42
 Weighted Mean 1.06 0.64 0.80 0.75 +.26 to +.42
2 SEM
 Median 2.16 1.33 1.53 1.46 +.63 to +.83
 Weighted Mean 2.12 1.29 1.59 1.50 +.53 to +.83
Responsiveness
SRM for improvement, retrospective
 Median 0.93 0.98 0.89 0.86 −.05 to +.07
 Weighted Mean 0.89 0.90 0.81 0.84 −.01 to +.08
SRM for improvement, prospective
 Median 0.85 0.76 0.75 0.72 +.09 to +.13
 Weighted Mean 1.01 0.92 0.86 0.90 +.09 to +.15
AUC for any improvement
 Median 0.73 0.77 0.73 0.75 −.04 to +.00
 Weighted Mean 0.71 0.74 0.70 0.74 −.03 to +.01
AUC for moderate improvement
 Median 0.74 0.77 0.71 0.76 −.03 to +.04
 Weighted Mean 0.72 0.75 0.70 0.76 −.04 to +.02
Between-group Treatment Effect Size
 Median 0.52 0.58 0.46 0.56 −.06 to +.06
 Weighted Mean 0.51 0.57 0.50 0.52 −.06 to +.01
*

Range of differences between the PEG and the 3 BPI MID/responsiveness metrics calculated as PEG metric minus BPI metric. For example, the PEG-BPI difference in the 6 trials for the 0.50 standard deviation weighted mean is 1.09 – 1.03 = +.06 for the PEG-BPI Total difference; 1.09 – 1.16 = −.07 for the PEG-BPI Interference difference; and 1.09 – 0.92 = +.17 for the PEG-BPI Severity difference. Thus, the range is −.07 to +.17