Table 1.
Studies of cerebral asymmetry in the human brain
| Methods and measurements | Main findings of the study | |
|---|---|---|
| Lyttelton et al. (2009), 112 right-handed subjects | SBM-based vertex-wise analysis of SA and positional asymmetry | SA asymmetry to the left in supramarginal gyrus, Heschl’s gyrus, PT, anterior superior temporal, lateral orbital frontal cortex, and to the right in anterior occipital lobe, dorsal anterior cingulate, and medial orbital frontal; positional asymmetry in the pattern of the cerebral torque |
| Zhou et al. (2013), 274 right-handed subjects | SBM-based vertex-wise analysis of CT asymmetry | CT asymmetry emerges extensively after adolescence and becomes more pronounced with age |
| Meyer et al. (2014), 104 healthy subjects | Destrieux atlas–based ROI analysis of GMV, SA, and CT asymmetry | Global rightward asymmetry in GMV and SA but not CT; leftward SA asymmetry in auditory-related cortex and rightward CT asymmetry in primary and secondary auditory cortex |
| Koelkebeck et al. (2014), 101 right-handed subjects | Desikan-Killiany atlas–based ROI analysis of GMV, SA, and CT asymmetry | Different patterns of asymmetry in different measures; more prominent SA asymmetry compared with CT asymmetry |
| Maingault et al. (2016), 250 subjects (130 right-handed) | SBM-based vertex-wise analysis of GMV, SA, CT, and sulcal depth asymmetry | Global GMV, SA, and CT asymmetry to the right; no significant correlation between global SA and CT asymmetry; handedness is not associated with cortical asymmetries |
| Chiarello et al. (2016), 200 healthy subjects | Destrieux atlas–based ROI analysis of SA, CT, and LGI asymmetry | Extensive asymmetries of all three measures; substantial differences between different measures in both pattern and extent; regions with larger between-subject variability also show greater asymmetry |
| Kong et al. (2018), 17 141 healthy subjects | Desikan-Killiany atlas–based ROI analysis of SA, CT asymmetry | Global rightward asymmetry in SA and leftward asymmetry in CT; substantial and differential regional asymmetry in SA and CT which interacts with sex, age, and ICV; no overall correlation between SA and CT asymmetry; handedness is not associated with cortical asymmetries |
| Le Guen, Leroy, et al. (2018), 800+ subjects from the Human Connectome Project (HCP) | Novel ROI–based analysis of sulcal pit distribution asymmetry | Sulcal pit asymmetry in STS reported to be genetically determined |
Note: Gray Matter Volume (GMV), Local Gyrification Index (LGI) and Intra Cranial Volume (ICV).