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. 2023 Jun 14;27(1):18–26. doi: 10.1016/j.cjtee.2023.06.002

Fig. 3.

Fig. 3

CGRP alleviates brain injury in heatstroke. (A & B) CGRP expression was detected by immunohistochemistry in cerebral cortex and hippocampus. (C) Corresponding quantifications of positive cells were calculated. ∗p < 0.05 vs. control group, #p < 0.05 vs. control group. (D) CGRP mRNA expression was detected by qPCR. ∗p < 0.05 vs. control group. (E) Serum NSE and S100B were detected by ELISA. ∗p < 0.05 vs. control group, #p < 0.05 vs. HS group. (F) Active caspase-3 expression was detected by immunohistochemistry in cerebral cortex of Control, HS, HS+CGRP, HS+CGRP8-37 group rats. (G) Corresponding quantifications of positive cells were calculated and shown. ∗p < 0.05 vs. control group, #p < 0.05 vs. HS group.

CGRP: calcitonin gene-related peptide; NSE: neuron-specific enolase; ELISA: Enzyme linked immunosorbent assay; HS: heatstroke.