Skip to main content
. 2023 Jun 14;27(1):18–26. doi: 10.1016/j.cjtee.2023.06.002

Fig. 4.

Fig. 4

CGRP inhibits neuron apoptosis via PKA/p-CREB. (A) Expression of PKA on cerebral cortex neurons in Wistar rats in each group detecting by western blot. Left: diagram of gel electrophoresis. Right: statistical graph. (B) Expression of p-CREB on Wistar rat cortical neuronal cells in each group detecting by western blot. Left: diagram of gel electrophoresis. Right: statistical graph. ∗p < 0.05 vs. control group, #p < 0.05 vs. HS group. (C) Apoptosis rate was detected by flow cytometry. A1-A5 corresponded to control group, HS group, HS+CGRP group, HS+CGRP8-37 group, and HS+CGRP+H89 group. (D) Expression of active caspase-3 on Wistar rat cortical neuronal cells in each group was detected by western blot. Left: diagram of gel electrophoresis. Right: statistical graph. ∗p < 0.05 vs. control group, #p < 0.05 vs. HS group.

CGRP: calcitonin gene-related peptide; CREB: cAMP response element-binding protein; PKA: protein kinase A; HS: heatstroke.