Table 1.
Values showing the % Prevention of lysis and % NO release of synthesized compound 5a-j.
| Compound Code | R |
Activity (% prevention of lysis) |
% NO release | |||
|---|---|---|---|---|---|---|
| 25 µg/mL | 25 µg/mL | 25 µg/mL | 25 µg/mL | |||
| 5a | H | 56.64 | 57.08 | 61.20 | 62.26 | 20.86 |
| 5b | 4-Br-Ph- | 38.53 | 43.66 | 58.61 | 67.11 | 11.23 |
| 5c | 4-Cl-Ph- | 42.98 | 51.46 | 56.50 | 65.39 | 14.31 |
| 5d | 2-CH3-Ph- | 52.34 | 54.62 | 55.87 | 55.60 | 11.26 |
| 5e | 3-CH3-Ph- | 51.21 | 51.96 | 60.20 | 61.22 | 13.02 |
| 5f | 4-CH3-Ph- | 39.94 | 46.46 | 49.58 | 52.29 | 11.51 |
| 5g | 1-Naphthyl- | 50.01 | 51.07 | 62.36 | 53.86 | 18.20 |
| 5h | –NH-Ph | 53.88 | 54.98 | 61.34 | 58.50 | 17.82 |
| 5i | 4-COOH-Ph- | nd | nd | nd | nd | nd |
| 5j | 4-CH3CONH-Ph- | 55.07 | 56.00 | 60.05 | 66.89 | 15.72 |
| Aspirin | 36.02 | 54.44 | 62.06 | 76.06 | – | |