TABLE 1.
Comparison of patients with and without early‐onset T2DM.
| Variables | All (n = 1225) | Control group (n = 619) | Early‐onset T2DM group (n = 606) | P value |
|---|---|---|---|---|
| Gender (%) | .842 | |||
| Male | 950 (77.6) | 482 (77.9) | 468 (77.2) | |
| Female | 275 (22.4) | 137 (22.1) | 138 (22.8) | |
| Onset age (year) | 31.16 ± 0.16 | 31.06 ± 0.23 | 31.36 ± 0.24 | .225 |
| SBP (mm Hg) | 122.09 ± 0.44 | 117.35 ± 0.54 | 126.93 ± 0.64 | <.0001 |
| DBP (mm Hg) | 78.94 ± 0.34 | 76.49 ± 0.44 | 81.44 ± 0.49 | <.0001 |
| BMI (kg/m2) | 26.15 ± 0.14 | 24.46 ± 0.16 | 27.88 ± 0.21 | <.0001 |
| Weight (kg) | 76.88 ± 0.50 | 71.79 ± 0.60 | 82.07 ± 0.73 | <.0001 |
| Height (cm) | 171.00 ± 0.26 | 170.86 ± 0.40 | 171.15 ± 0.32 | .576 |
| Smoking status (%) | .097 | |||
| Yes | 556 (45.4) | 266 (43.0) | 290 (47.9) | |
| No | 669 (54.6) | 353 (57.0) | 316 (52.1) | |
| Drink (%) | <.0001 | |||
| Yes | 426 (34.8) | 176 (28.4) | 250 (41.3) | |
| No | 799 (65.2) | 443 (71.6) | 356 (58.7) | |
| DM family history (%) | <.0001 | |||
| Yes | 355 (29.0) | 25 (4.0) | 330 (54.5) | |
| No | 870 (71.0) | 594 (96.0) | 276 (45.5) | |
| FBG (mmol/L) | 7.28 ± 0.11 | 4.86 ± 0.02 | 9.76 ± 0.17 | <.0001 |
| HbA1c (%) | 7.48 ± 0.08 | 5.32 ± 0.01 | 9.68 ± 0.11 | <.0001 |
| Fatty liver (%) | <.0001 | |||
| Yes | 711 (58.0) | 264 (42.6) | 450 (74.3) | |
| No | 513 (41.9) | 355 (57.4) | 156 (25.7) | |
| WHR | 0.93 ± 0.23 | 0.89 ± 0.003 | 0.97 ± 0.003 | <.0001 |
| eGFR (ml/min/1.73 m2) | 107.20 ± 0.77 | 120.10 ± 1.19 | 94.57 ± 0.63 | <.0001 |
| UA (umol/L) | 370.57 ± 4.60 | 371.05 ± 3.80 | 370.09 ± 8.47 | .918 |
| TG (mmol/L) | 1.67 (1.06, 2.64) | 1.36 (0.88, 2.14) | 2.04 (1.32, 3.23) | <.0001 |
| TC (mmol/L) | 4.80 ± 0.04 | 4.69 ± 0.04 | 4.91 ± 0.07 | <.0001 |
| HDL‐C (mmol/L) | 1.09 ± 0.01 | 1.24 ± 0.01 | 0.93 ± 0.01 | <.0001 |
| LDL‐C (mmol/L) | 3.03 ± 0.03 | 2.94 ± 0.04 | 3.11 ± 0.03 | <.0001 |
| ALT (U/L) | 25.50 (14.90, 44.40) | 21.90 (12.80, 36.30) | 29.30 (18.00, 55.13) | <.0001 |
| AST (U/L) | 25.23 ± 0.62 | 22.18 ± 0.53 | 28.35 ± 1.11 | <.0001 |
| GGT (U/L) | 46.35 ± 1.64 | 41.56 ± 1.80 | 51.23 ± 2.75 | .003 |
| WBC (109/L) | 6.77 ± 0.05 | 6.50 ± 0.07 | 7.05 ± 0.08 | <.0001 |
| Neutrophil (%) | 0.55 ± 0.003 | 0.55 ± 0.003 | 0.54 ± 0.004 | .609 |
| NLR | 1.71 ± 0.02 | 1.72 ± 0.03 | 1.70 ± 0.04 | .709 |
| Lymphocyte (%) | 0.35 ± 0.002 | 0.34 ± 0.003 | 0.36 ± 0.004 | <.0001 |
| Monocyte (%) | 0.07 ± 0.001 | 0.08 ± 0.001 | 0.06 ± 0.0008 | <.0001 |
| MLR | 0.21 ± 0.003 | 0.23 ± 0.005 | 0.19 ± 0.004 | <.0001 |
| Platelet (109/L) | 250.52 ± 1.76 | 251.17 ± 2.11 | 249.85 ± 2.83 | .708 |
| PHR | 253.59 ± 2.96 | 216.49 ± 2.99 | 291.49 ± 4.66 | <.0001 |
| RC (mmol/L) | 0. 400.15,0.74) | 0.20 (0.07,0.41) | 0.64 (0.39,1.05) | <.0001 |
| LDL‐C/HDL‐C | 3.02 ± 0.03 | 2.69 ± 0.04 | 3.36 ± 0.05 | <.0001 |
| TG/HDL‐C | 1.65 (0.87,2.91) | 1.15 (0.62,2.04) | 2.31 (1.41,4.04) | <.0001 |
| TC/HDL‐C | 4.88 ± 0.07 | 4.03 ± 0.05 | 5.76 ± 0.12 | <.0001 |
Abbreviations: ALT, alanine aminotransferase; AST, aspartic transaminase; BMI, body mass index; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; FBG, fasting blood‐glucose; GGT, gamma‐glutamyl transpeptidase; HbA1c, glycosylated hemoglobin; HDL‐C, high‐density lipoprotein cholesterol; LDL‐C, low‐density lipoprotein cholesterol; LDL‐C/HDL‐C, LDL‐C/HDL‐C ratio; MLR, monocyte to lymphocyte ratio; NLR, neutrophil to lymphocyte ratio; PHR, platelet/HDL‐C ratio; RC, remnant cholesterol; SBP, systolic blood pressure; T2DM, type 2 diabetes mellitus; TC, total cholesterol; TC/HDL‐C, TC/HDL‐C ratio; TG, triglyceride; TG/HDL‐C, TG/HDL‐C ratio; UA, uric acid; WBC, white blood cell; WHR, waist‐to‐hip ratio.